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We performed fast fluid-attenuated inversion recovery(fFLAIR)and conventional spin echo(CSE)brain MRI in 32 multiple sclerosis(MS)patients (eight each benign,relapsing-remitting,primary progressive,and secondary progressive).We compared number and site of lesions detected on each sequence.With initial separate assessment,we identified a total of 3,668 lesions-2,892 by CSE and 2,943 by fFLAIR.Following simultaneous review of posterior fossa(66 versus 138,p=0.001),fewer small(<5mm)discrete cerebral white matter lesions(671 versus 829,p=0.0002),more subcortical lesions(542 versus 306,p<0.0001),and more large discrete lesions(419 versus 385,p=0. 0006).Its relatively poor detection of posterior fossa lesions makes it premature for fFLAIR to replace CSE as the primary sequence for detecting MS lesions in clinical trials. |
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